The structure of sucrose synthase-1 from arabidopsis thaliana and its functional implications

Yi Zheng, Spencer Anderson, Yanfeng Zhang, R. Michael Garavito*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Sucrose transport is the central system for the allocation of carbon resources in vascular plants. During growth and development, plants control carbon distribution by coordinating sites of sucrose synthesis and cleavage in different plant organs and different cellular locations. Sucrose synthase, which reversibly catalyzes sucrose synthesis and cleavage, provides a direct and reversible means to regulate sucrose flux. Depending on the metabolic environment, sucrose synthase alters its cellular location to participate in cellulose, callose, and starch biosynthesis through its interactions with membranes, organelles, and cytoskeletal actin. The x-ray crystal structure of sucrose synthase isoform 1 from Arabidopsis thaliana (AtSus1) has been determined as a complex with UDP-glucose and as a complex with UDP and fructose, at 2.8- and 2.85-Å resolutions, respectively. The AtSus1 structure provides insights into sucrose catalysis and cleavage, as well as the regulation of sucrose synthase and its interactions with cellular targets.

Original languageEnglish (US)
Pages (from-to)36108-36118
Number of pages11
JournalJournal of Biological Chemistry
Issue number41
StatePublished - Oct 14 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology


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