The structures that underlie normal reproductive function

Thomas F. Lerch; Min Xu; Theodore S. Jardetzky; Kelly E. Mayo; Ishwar Radhakrishnan; Ralph Kazer; Lonnie D. Shea; Teresa K. Woodruff

doi:10.1016/j.mce.2006.10.018

The structures that underlie normal reproductive function

Thomas F. Lerch, Min Xu, Theodore S. Jardetzky, Kelly E. Mayo, Ishwar Radhakrishnan, Ralph Kazer, Lonnie D. Shea, Teresa K. Woodruff^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies have provided unprecedented insights into reproductive systems and signaling networks. This 'cutting edge' editorial provides a recent example in each of these areas, namely, the anatomical integrity of the follicle, the molecular structure of activin with its binding partners and the molecular regulation of inhibin. These three examples of structure informing function help explain reproductive health and may provide solutions to reproductive disease.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Molecular and Cellular Endocrinology
Volume	267
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2006.10.018
State	Published - Mar 15 2007

Funding

This work was supported by NIH grant U54 HD041857 to T.K.W., K.E.M., I.R., and T.J. and by Core B of NIH grant P0 HD021921. T.F.L. is supported by the Cellular and Molecular Basis for Disease training grant (T32 GM008061). We would also like to thank members of the Jardetzky and Woodruff labs for critical reading of this manuscript and to Tyler Wellington for tissue section images.

Keywords

Activin
Follicle
Follistatin
Inhibin
Ovary
Structure

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2006.10.018

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title = "The structures that underlie normal reproductive function",

abstract = "The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies have provided unprecedented insights into reproductive systems and signaling networks. This 'cutting edge' editorial provides a recent example in each of these areas, namely, the anatomical integrity of the follicle, the molecular structure of activin with its binding partners and the molecular regulation of inhibin. These three examples of structure informing function help explain reproductive health and may provide solutions to reproductive disease.",

keywords = "Activin, Follicle, Follistatin, Inhibin, Ovary, Structure",

author = "Lerch, {Thomas F.} and Min Xu and Jardetzky, {Theodore S.} and Mayo, {Kelly E.} and Ishwar Radhakrishnan and Ralph Kazer and Shea, {Lonnie D.} and Woodruff, {Teresa K.}",

note = "Funding Information: This work was supported by NIH grant U54 HD041857 to T.K.W., K.E.M., I.R., and T.J. and by Core B of NIH grant P0 HD021921. T.F.L. is supported by the Cellular and Molecular Basis for Disease training grant (T32 GM008061). We would also like to thank members of the Jardetzky and Woodruff labs for critical reading of this manuscript and to Tyler Wellington for tissue section images.",

year = "2007",

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doi = "10.1016/j.mce.2006.10.018",

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AU - Xu, Min

AU - Jardetzky, Theodore S.

AU - Mayo, Kelly E.

AU - Radhakrishnan, Ishwar

AU - Kazer, Ralph

AU - Shea, Lonnie D.

AU - Woodruff, Teresa K.

N1 - Funding Information: This work was supported by NIH grant U54 HD041857 to T.K.W., K.E.M., I.R., and T.J. and by Core B of NIH grant P0 HD021921. T.F.L. is supported by the Cellular and Molecular Basis for Disease training grant (T32 GM008061). We would also like to thank members of the Jardetzky and Woodruff labs for critical reading of this manuscript and to Tyler Wellington for tissue section images.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies have provided unprecedented insights into reproductive systems and signaling networks. This 'cutting edge' editorial provides a recent example in each of these areas, namely, the anatomical integrity of the follicle, the molecular structure of activin with its binding partners and the molecular regulation of inhibin. These three examples of structure informing function help explain reproductive health and may provide solutions to reproductive disease.

AB - The mechanisms and physiology of reproductive function have fascinated scientists throughout time. Recent cellular and molecular level structural studies have provided unprecedented insights into reproductive systems and signaling networks. This 'cutting edge' editorial provides a recent example in each of these areas, namely, the anatomical integrity of the follicle, the molecular structure of activin with its binding partners and the molecular regulation of inhibin. These three examples of structure informing function help explain reproductive health and may provide solutions to reproductive disease.

KW - Activin

KW - Follicle

KW - Follistatin

KW - Inhibin

KW - Ovary

KW - Structure

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The structures that underlie normal reproductive function

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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