TY - JOUR
T1 - The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel
AU - Burke, Michael A.
AU - Mutharasan, R. Kannan
AU - Ardehali, Hossein
PY - 2008/2
Y1 - 2008/2
N2 - ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad critical cellular processes, from nutrient import to toxin efflux using the energy derived from ATP hydrolysis. Most ABC proteins mediate transport of substances across lipid membranes. However, there are atypical ABC proteins that mediate other processes. These include, but are not limited to, DNA repair (bacterial MutS), ion transport (cystic fibrosis transmembrane receptor), and mRNA trafficking (yeast Elf1p). The sulfonylurea receptor (SUR) is another atypical ABC protein that regulates activity of the potassium ATP channel (KATP). KATP is widely expressed in nearly all tissues of higher organisms and couples cellular energy status to membrane potential. KATP is particularly important in the regulation of insulin secretion from pancreatic β-cells and in regulating action potential duration in muscle cells. SUR is indispensable for normal channel function, and mutations in genes encoding SURs increase the susceptibility to diabetes, myocardial infarction, and heart failure. Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the KATP channel, and its role in cardiovascular disease.
AB - ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad critical cellular processes, from nutrient import to toxin efflux using the energy derived from ATP hydrolysis. Most ABC proteins mediate transport of substances across lipid membranes. However, there are atypical ABC proteins that mediate other processes. These include, but are not limited to, DNA repair (bacterial MutS), ion transport (cystic fibrosis transmembrane receptor), and mRNA trafficking (yeast Elf1p). The sulfonylurea receptor (SUR) is another atypical ABC protein that regulates activity of the potassium ATP channel (KATP). KATP is widely expressed in nearly all tissues of higher organisms and couples cellular energy status to membrane potential. KATP is particularly important in the regulation of insulin secretion from pancreatic β-cells and in regulating action potential duration in muscle cells. SUR is indispensable for normal channel function, and mutations in genes encoding SURs increase the susceptibility to diabetes, myocardial infarction, and heart failure. Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the KATP channel, and its role in cardiovascular disease.
KW - ATP-binding cassette (ABC) protein
KW - K
KW - Myocardium
KW - SUR2
KW - Sulfonylurea receptor
UR - http://www.scopus.com/inward/record.url?scp=41149127307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41149127307&partnerID=8YFLogxK
U2 - 10.1161/CIRCRESAHA.107.165324
DO - 10.1161/CIRCRESAHA.107.165324
M3 - Review article
C2 - 18239147
AN - SCOPUS:41149127307
SN - 0009-7330
VL - 102
SP - 164
EP - 176
JO - Circulation research
JF - Circulation research
IS - 2
ER -