The super elongation complex (SEC) family in transcriptional control

Zhuojuan Luo, Chengqi Lin, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations

Abstract

The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. It is one of the most active P-TEFb-containing complexes required for rapid transcriptional induction in the presence or absence of paused Pol II. The SEC was found to regulate the transcriptional elongation checkpoint control (TECC) stage of transcription, and misregulation of this stage is associated with cancer pathogenesis. Recent studies have shown that the SEC belongs to a larger family of SEC-like complexes, which includes SEC-L2 and SEC-L3, each with distinct gene target specificities.

Original languageEnglish (US)
Pages (from-to)543-547
Number of pages5
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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