The synapsins: Beyond the regulation of neurotransmitter release

A. Ferreira*, M. Rapoport

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


The synapsins are a family of five closely related neuron-specific phosphoproteins associated with the membranes of synaptic vesicles. The synapsins have been implicated in the regulation of neurotransmitter release. They tether synaptic vesicles to actin filaments in a phosphorylation-dependent manner, controlling the number of vesicles available for release at the nerve terminus. A growing body of evidence suggests that the synapsins play a broad role during neuronal development. They participate in the formation and maintenance of synaptic contacts among central neurons. In addition, each synapsin has a specific role during the elongation of undifferentiated processes and their posterior differentiation into axons and dendrites. In this review, we focus on these novel roles of synapsins during the early stages of development.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalCellular and Molecular Life Sciences
Issue number4
StatePublished - 2002


  • Axonal differentiation
  • Mental diseases
  • Neurite elongation
  • Synapsins
  • Synaptogenesis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology
  • Pharmacology


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