The syndrome of therapy-related myelodysplasia and myeloid leukemia

Lucy A. Godley, Richard A. Larson

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Scopus citations


Patients who have received cytotoxic therapy with chemotherapy drugs and/or radiotherapy are at risk for long-term complications from their treatment. One of the most grave of these is the development of myelodysplasia or acute myeloid leukemia. Although a causal link has not yet been proven, these neoplasms are thought to be a direct consequence of mutational events caused by cytotoxic therapy and to be independent of the primary disease. Thus, they have been termed “therapy-related myelodysplastic syndrome” (t-MDS) and “therapyrelated acute myeloid leukemia” (t-AML).

Original languageEnglish (US)
Title of host publicationThe Myelodysplastic Syndromes
Subtitle of host publicationPathobiology and Clinical Management
PublisherCRC Press
Number of pages38
ISBN (Electronic)9780203908853
ISBN (Print)9781135559625
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Medicine(all)


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