The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

Achintya Bandyopadhyaya, Desikan R. Rajagopalan, Nigam P. Rath, Amy Herrold, Raghavan Rajagopalan, T. Celesete Napier, Clark E. Tedford, Parthasarathi Rajagopalan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.

Original languageEnglish (US)
Pages (from-to)580-583
Number of pages4
JournalMedChemComm
Volume3
Issue number5
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

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