TY - JOUR
T1 - The tectorial membrane
T2 - Mechanical properties and functions
AU - Sellon, Jonathan B.
AU - Ghaffari, Roozbeh
AU - Freeman, Dennis M.
N1 - Publisher Copyright:
© 2019 Cold Spring Harbor Laboratory Press.
PY - 2019/10
Y1 - 2019/10
N2 - The tectorial membrane (TM) is widely believed to play a critical role in determining the remarkable sensitivity and frequency selectivity that are hallmarks of mammalian hearing. Recently developed mouse models of human hearing disorders have provided new insights into the molecular, nanomechanical mechanisms that underlie resonance and traveling wave properties of the TM. Herein we review recent experimental and theoretical results detailing TM morphology, local poroelastic and electromechanical interactions, and global spread of excitation via TM traveling waves, with direct implications for cochlear mechanisms.
AB - The tectorial membrane (TM) is widely believed to play a critical role in determining the remarkable sensitivity and frequency selectivity that are hallmarks of mammalian hearing. Recently developed mouse models of human hearing disorders have provided new insights into the molecular, nanomechanical mechanisms that underlie resonance and traveling wave properties of the TM. Herein we review recent experimental and theoretical results detailing TM morphology, local poroelastic and electromechanical interactions, and global spread of excitation via TM traveling waves, with direct implications for cochlear mechanisms.
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U2 - 10.1101/cshperspect.a033514
DO - 10.1101/cshperspect.a033514
M3 - Article
C2 - 30348837
AN - SCOPUS:85072849145
SN - 2157-1422
VL - 9
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 10
M1 - a033514
ER -