The therapeutic effects of cellular therapy for functional recovery after brain injury

Richard L. Harvey*, Michael Chopp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The studies presented in this article suggest that marrow-derived cellular therapy may be an effective adjunct treatment for functional recovery after stroke. Cellular therapy can enhance the endogenous restorative mechanisms of the injured brain, assisting the tissue as it returns to a "developmental" state and supporting the process of neovascularization, neurogenesis, and neural reorganization. The advantages of using MSCs are that they can be given as an autologous graft, avoiding risks of rejection and graft-versus-host reactions, and that they can be given intravenously, minimizing complications. It is anticipated that cellular therapy, in combination with standard rehabilitation therapy and neural retraining, can improve functional outcomes following stroke.

Original languageEnglish (US)
Pages (from-to)S143-S151
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume14
Issue number1 SUPPL.
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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