The thrombophilic state in acute promyelocytic leukemia

Martin S. Tallman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Acute promyelocytic leukemia is characterized by the association with a severe coagulopathy resulting in hemorrhagic manifestations. The pathogenesis underlying the hemorrhagic syndrome is complex and involves the activation of the coagulation cascade and the fibrinolytic system. All-trans-retinoic acid (ATRA) appears to correct both procoagulant and fibrinolytic activities in vitro and in vivo. Early results of treatment with arsenic trioxide, which acts by inducing apoptosis of the leukemic promyelocytes, also show regression in the coagulopathy with a decrease in fibrin degradation products and D-Dimer. A clear understanding of the relationship between laboratory changes and the effects of ATRA and arsenic trioxide requires further studies.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalSeminars in thrombosis and hemostasis
Issue number2
StatePublished - 1999
Externally publishedYes


  • Acute promyelocytic leukemia
  • All-trans-retinoic acid
  • Coagulopathy
  • Disseminated intravascular coagulation (DIC)
  • Hemorrhage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


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