The time has come to change the algorithm for the surgical management of early breast cancer

Nora M. Hansen*, Baiba J. Grube, Armando E. Giuliano

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Hypothesis: If the sentinel lymph nodes (SNs) draining a primary invasive breast cancer are free of tumor, then axillary lymph node dissection is not necessary for management of disease. Design and Intervention: In July 2000, we reported our initial experience of a small cohort of patients who underwent axillary lymph node dissection only if their SNs were involved with metastases. We now report outcome data for all patients who underwent breast conservation and sentinel lymph node dissection without completion axillary lymph node dissection between October 1, 1995, and April 30, 1999. Setting: Tertiary breast referral center. Patients: Two hundred thirty-eight patients whose SN staining results were negative for tumor by both hematoxylin-eosin and imunohistochemical stains. Median age was 58.4 years. Most patients (85%) had a T1 tumor; 15% had a T2 tumor. Most (86%) had infiltrating ductal carcinoma with or without extensive ductal carcinoma in situ; 10% had invasive lobular cancer. Results: At a median follow-up of 38.9 months (range, 6-69 months), we found no axillary recurrences, and 98.3% of patients are alive without evidence of disease. Three patients have died of causes not related to breast cancer. Four patients are alive with metastatic disease but have not developed axillary recurrences. Conclusions: Sentinel lymph node dissection is a safe and efficacious treatment option for patients with early breast cancer. It provides excellent regional control and is associated with excellent survival. A multicenter trial such as the American College of Surgeons Oncology Group Z0010 is needed to corroborate findings of this single-institution study.

Original languageEnglish (US)
Pages (from-to)1131-1135
Number of pages5
JournalArchives of Surgery
Volume137
Issue number10
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Surgery

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