The TNF receptor 1: A split personality complex

Bryan C. Barnhart*, Marcus E. Peter

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


The tumor necrosis factor receptor 1 (TNFR1), a prototypic member of the death receptor family signals both cell survival and apoptosis. In this issue of Cell, Micheau and Tschopp (2003) report that apoptotic TNFR1 signaling proceeds via the sequential formation of two distinct complexes. Since the first complex can activate survival signals and influence the activity of the second complex, this mechanism provides a checkpoint to control the execution of apoptosis.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
Issue number2
StatePublished - Jul 25 2003

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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