The TO strains of Theiler's viruses cause “slow virus—like” infections in mice

Howard L. Lipton*, Mauro C. Dal Canto

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Intracerebral inoculation of mice with tissue culture–adapted TO strains of Theiler's mouse encephalomyelitis viruses results in a clinical disease consisting of spastic paralysis due to demyelination after a lengthy incubation period. Thus, in effect, these ordinary picornaviruses are capable of causing a slow infection in their natural host, the mouse. In addition, through the use of tissue culture–adapted virus stocks, virus content in mouse tissues now can be accurately quantified by standard plaque assay.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalAnnals of neurology
Volume6
Issue number1
DOIs
StatePublished - Jul 1979

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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