The TO strains of Theiler's viruses cause “slow virus—like” infections in mice

Howard L. Lipton; Mauro C. Dal Canto

doi:10.1002/ana.410060106

The TO strains of Theiler's viruses cause “slow virus—like” infections in mice

Howard L. Lipton^*, Mauro C. Dal Canto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Intracerebral inoculation of mice with tissue culture–adapted TO strains of Theiler's mouse encephalomyelitis viruses results in a clinical disease consisting of spastic paralysis due to demyelination after a lengthy incubation period. Thus, in effect, these ordinary picornaviruses are capable of causing a slow infection in their natural host, the mouse. In addition, through the use of tissue culture–adapted virus stocks, virus content in mouse tissues now can be accurately quantified by standard plaque assay.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Annals of neurology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/ana.410060106
State	Published - Jul 1979
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Neurology

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abstract = "Intracerebral inoculation of mice with tissue culture–adapted TO strains of Theiler's mouse encephalomyelitis viruses results in a clinical disease consisting of spastic paralysis due to demyelination after a lengthy incubation period. Thus, in effect, these ordinary picornaviruses are capable of causing a slow infection in their natural host, the mouse. In addition, through the use of tissue culture–adapted virus stocks, virus content in mouse tissues now can be accurately quantified by standard plaque assay.",

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AB - Intracerebral inoculation of mice with tissue culture–adapted TO strains of Theiler's mouse encephalomyelitis viruses results in a clinical disease consisting of spastic paralysis due to demyelination after a lengthy incubation period. Thus, in effect, these ordinary picornaviruses are capable of causing a slow infection in their natural host, the mouse. In addition, through the use of tissue culture–adapted virus stocks, virus content in mouse tissues now can be accurately quantified by standard plaque assay.

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The TO strains of Theiler's viruses cause “slow virus—like” infections in mice

Abstract

ASJC Scopus subject areas

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