The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.

R. A. Clift; C. D. Buckner; E. D. Thomas; K. J. Kopecky; F. R. Appelbaum; M. Tallman; R. Storb; J. Sanders; K. Sullivan; M. Banaji

The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.

R. A. Clift^*, C. D. Buckner, E. D. Thomas, K. J. Kopecky, F. R. Appelbaum, M. Tallman, R. Storb, J. Sanders, K. Sullivan, M. Banaji

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

The results are presented of allogeneic transplantation for 363 patients with acute non-lymphoblastic leukemia treated in Seattle from May 1973 through December 1985. The probabilities of surviving disease-free for 5 years for patients transplanted in first remission, in second remission, in untreated first relapse or in chemotherapy-resistant first relapse were 46%, 28%, 30%, and 21%, respectively. The corresponding probabilities of relapse within 5 years were 25%, 37%, 36% and 56%, respectively. Prognostic factors predictive of survival after marrow transplantation for patients transplanted in first remission included age, donor sex and the number of circulating blasts at the time of diagnosis. Acute graft-versus-host disease (GVHD) had a major adverse effect on survival, but chronic GVHD decreased the risk of relapse for patients transplanted in first remission.

Original language	English (US)
Pages (from-to)	243-258
Number of pages	16
Journal	Bone Marrow Transplantation
Volume	2
Issue number	3
State	Published - Oct 1987

ASJC Scopus subject areas

Hematology
Transplantation

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title = "The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.",

abstract = "The results are presented of allogeneic transplantation for 363 patients with acute non-lymphoblastic leukemia treated in Seattle from May 1973 through December 1985. The probabilities of surviving disease-free for 5 years for patients transplanted in first remission, in second remission, in untreated first relapse or in chemotherapy-resistant first relapse were 46%, 28%, 30%, and 21%, respectively. The corresponding probabilities of relapse within 5 years were 25%, 37%, 36% and 56%, respectively. Prognostic factors predictive of survival after marrow transplantation for patients transplanted in first remission included age, donor sex and the number of circulating blasts at the time of diagnosis. Acute graft-versus-host disease (GVHD) had a major adverse effect on survival, but chronic GVHD decreased the risk of relapse for patients transplanted in first remission.",

author = "Clift, {R. A.} and Buckner, {C. D.} and Thomas, {E. D.} and Kopecky, {K. J.} and Appelbaum, {F. R.} and M. Tallman and R. Storb and J. Sanders and K. Sullivan and M. Banaji",

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AU - Clift, R. A.

AU - Buckner, C. D.

AU - Thomas, E. D.

AU - Kopecky, K. J.

AU - Appelbaum, F. R.

AU - Tallman, M.

AU - Storb, R.

AU - Sanders, J.

AU - Sullivan, K.

AU - Banaji, M.

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N2 - The results are presented of allogeneic transplantation for 363 patients with acute non-lymphoblastic leukemia treated in Seattle from May 1973 through December 1985. The probabilities of surviving disease-free for 5 years for patients transplanted in first remission, in second remission, in untreated first relapse or in chemotherapy-resistant first relapse were 46%, 28%, 30%, and 21%, respectively. The corresponding probabilities of relapse within 5 years were 25%, 37%, 36% and 56%, respectively. Prognostic factors predictive of survival after marrow transplantation for patients transplanted in first remission included age, donor sex and the number of circulating blasts at the time of diagnosis. Acute graft-versus-host disease (GVHD) had a major adverse effect on survival, but chronic GVHD decreased the risk of relapse for patients transplanted in first remission.

AB - The results are presented of allogeneic transplantation for 363 patients with acute non-lymphoblastic leukemia treated in Seattle from May 1973 through December 1985. The probabilities of surviving disease-free for 5 years for patients transplanted in first remission, in second remission, in untreated first relapse or in chemotherapy-resistant first relapse were 46%, 28%, 30%, and 21%, respectively. The corresponding probabilities of relapse within 5 years were 25%, 37%, 36% and 56%, respectively. Prognostic factors predictive of survival after marrow transplantation for patients transplanted in first remission included age, donor sex and the number of circulating blasts at the time of diagnosis. Acute graft-versus-host disease (GVHD) had a major adverse effect on survival, but chronic GVHD decreased the risk of relapse for patients transplanted in first remission.

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The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation.

Abstract

ASJC Scopus subject areas

UN SDGs

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