TY - JOUR
T1 - The treatment of postprandial hypotension in autonomic failure with 3,4- dl-threo-dihydroxyphenylserine
AU - Freeman, Roy
AU - Young, James
AU - Landsberg, Lewis
AU - Lipsitz, Lewis
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double- blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,4-DL-threodihydroxyphenylserine (DL-DOPS) on this condition. We measured blood pressure, heart rate, forearm vascular resistance, and plasma DL-DOPS and norepinephrine in 11 patients with autonomic failure. DL-DOPS attenuated the postprandial fall in blood pressure. This was associated with an increase in plasma norepinephrine and forearm vascular resistance. DL-DOPS therapy did not change the postprandial increase in heart rate. There was a trend toward increased supine hypertension associated with DL-DOPS treatment. This study shows that DL- DOPS is a promising treatment for postprandial hypotension and provides support for the hypothesis that postprandial hypotension is, at least in part, due to decreased activation of the sympathetic nervous system.
AB - Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double- blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,4-DL-threodihydroxyphenylserine (DL-DOPS) on this condition. We measured blood pressure, heart rate, forearm vascular resistance, and plasma DL-DOPS and norepinephrine in 11 patients with autonomic failure. DL-DOPS attenuated the postprandial fall in blood pressure. This was associated with an increase in plasma norepinephrine and forearm vascular resistance. DL-DOPS therapy did not change the postprandial increase in heart rate. There was a trend toward increased supine hypertension associated with DL-DOPS treatment. This study shows that DL- DOPS is a promising treatment for postprandial hypotension and provides support for the hypothesis that postprandial hypotension is, at least in part, due to decreased activation of the sympathetic nervous system.
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U2 - 10.1212/WNL.47.6.1414
DO - 10.1212/WNL.47.6.1414
M3 - Article
C2 - 8960720
AN - SCOPUS:0029774180
VL - 47
SP - 1414
EP - 1420
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 6
ER -