Abstract
Parasitic nematodes cause significant effects on humans each year, with the most prevalent being Ascaris lumbricoides. Benzimidazoles (BZ) are the most widely used anthelmintic drug in humans, and although the biology of resistance to this drug class is understood in some species, resistance is poorly characterized in ascarids. Models such as Caenorhabditis elegans were essential in developing our current understanding of BZ resistance, but more closely related model nematodes are needed to understand resistance in ascarids. Here, we propose a new ascarid model species that infects turkeys, Ascaridia dissimilis, to develop a better understanding of BZ resistance.
Original language | English (US) |
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Pages (from-to) | 405-409 |
Number of pages | 5 |
Journal | International Journal for Parasitology |
Volume | 53 |
Issue number | 8 |
DOIs | |
State | Published - Jul 2023 |
Funding
The authors would like to thank Amanda Shaver and Izzy Miller for editing and suggestions in the preparation of this manuscript. Figures were produced using BioRender.com. This work was supported by the National Institutes of Health National Institute of Allergy and Infectious Diseases (Grant Number R01AI153088 awarded to E.C.A.).
Keywords
- Anthelmintic resistance
- Ascarid
- Benzimidazole
- Model organism
ASJC Scopus subject areas
- Parasitology
- Infectious Diseases