The turkey ascarid, Ascaridia dissimilis, as a model genetic system

J. B. Collins; Erik C. Andersen

doi:10.1016/j.ijpara.2022.10.005

The turkey ascarid, Ascaridia dissimilis, as a model genetic system

J. B. Collins, Erik C. Andersen^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

Abstract

Parasitic nematodes cause significant effects on humans each year, with the most prevalent being Ascaris lumbricoides. Benzimidazoles (BZ) are the most widely used anthelmintic drug in humans, and although the biology of resistance to this drug class is understood in some species, resistance is poorly characterized in ascarids. Models such as Caenorhabditis elegans were essential in developing our current understanding of BZ resistance, but more closely related model nematodes are needed to understand resistance in ascarids. Here, we propose a new ascarid model species that infects turkeys, Ascaridia dissimilis, to develop a better understanding of BZ resistance.

Original language	English (US)
Journal	International Journal for Parasitology
DOIs	https://doi.org/10.1016/j.ijpara.2022.10.005
State	Accepted/In press - 2022

Keywords

Anthelmintic resistance
Ascarid
Benzimidazole
Model organism

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijpara.2022.10.005

Cite this

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title = "The turkey ascarid, Ascaridia dissimilis, as a model genetic system",

abstract = "Parasitic nematodes cause significant effects on humans each year, with the most prevalent being Ascaris lumbricoides. Benzimidazoles (BZ) are the most widely used anthelmintic drug in humans, and although the biology of resistance to this drug class is understood in some species, resistance is poorly characterized in ascarids. Models such as Caenorhabditis elegans were essential in developing our current understanding of BZ resistance, but more closely related model nematodes are needed to understand resistance in ascarids. Here, we propose a new ascarid model species that infects turkeys, Ascaridia dissimilis, to develop a better understanding of BZ resistance.",

keywords = "Anthelmintic resistance, Ascarid, Benzimidazole, Model organism",

author = "Collins, {J. B.} and Andersen, {Erik C.}",

note = "Funding Information: The authors would like to thank Amanda Shaver and Izzy Miller for editing and suggestions in the preparation of this manuscript. Figures were produced using BioRender.com. This work was supported by the National Institutes of Health National Institute of Allergy and Infectious Diseases (Grant Number R01AI153088 awarded to E.C.A.). Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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doi = "10.1016/j.ijpara.2022.10.005",

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journal = "International Journal for Parasitology",

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AU - Collins, J. B.

AU - Andersen, Erik C.

N1 - Funding Information: The authors would like to thank Amanda Shaver and Izzy Miller for editing and suggestions in the preparation of this manuscript. Figures were produced using BioRender.com. This work was supported by the National Institutes of Health National Institute of Allergy and Infectious Diseases (Grant Number R01AI153088 awarded to E.C.A.). Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Parasitic nematodes cause significant effects on humans each year, with the most prevalent being Ascaris lumbricoides. Benzimidazoles (BZ) are the most widely used anthelmintic drug in humans, and although the biology of resistance to this drug class is understood in some species, resistance is poorly characterized in ascarids. Models such as Caenorhabditis elegans were essential in developing our current understanding of BZ resistance, but more closely related model nematodes are needed to understand resistance in ascarids. Here, we propose a new ascarid model species that infects turkeys, Ascaridia dissimilis, to develop a better understanding of BZ resistance.

AB - Parasitic nematodes cause significant effects on humans each year, with the most prevalent being Ascaris lumbricoides. Benzimidazoles (BZ) are the most widely used anthelmintic drug in humans, and although the biology of resistance to this drug class is understood in some species, resistance is poorly characterized in ascarids. Models such as Caenorhabditis elegans were essential in developing our current understanding of BZ resistance, but more closely related model nematodes are needed to understand resistance in ascarids. Here, we propose a new ascarid model species that infects turkeys, Ascaridia dissimilis, to develop a better understanding of BZ resistance.

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KW - Ascarid

KW - Benzimidazole

KW - Model organism

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The turkey ascarid, Ascaridia dissimilis, as a model genetic system

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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