The Type i Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection

Daniel Giraldo, Douglas R. Wilcox, Richard Longnecker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection. In this study, we review the contribution of the type I IFN response to controlling HSV-1 infection, and differences in the early host response between adults and newborns that may contribute to the increased susceptibility to infection and central nervous system disease in newborns.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalDNA and Cell Biology
Volume36
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • HSV encephalitis
  • herpesvirus
  • interferon

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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