The type III secretion system of Pseudomonas aeruginosa: Infection by injection

Alan R. Hauser*

*Corresponding author for this work

Research output: Contribution to journalReview article

490 Scopus citations

Abstract

The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.

Original languageEnglish (US)
Pages (from-to)654-665
Number of pages12
JournalNature Reviews Microbiology
Volume7
Issue number9
DOIs
StatePublished - Aug 31 2009

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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