The ultrastructural effects of aflatoxin B1 in the rat pancreas

M. S. Rao; D. J. Svoboda; J. K. Reddy

doi:10.1007/BF02912843

The ultrastructural effects of aflatoxin B₁ in the rat pancreas

M. S. Rao, D. J. Svoboda, J. K. Reddy

Pathology

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Abstract

The acute effects of aflatoxin B₁ (AFB₁) on the morphology of the acinar cells of the exocrine pancreas were studied in rats. By light microscopy, the changes were unremarkable except for slight decrease in number of zymogen granules. By electron microscopy, the changes observed were: (a) decrease in the number of zymogen granules and irregularity of the limiting membrane, (b) dilatation of Golgi vesicles, (c) dilatation of endoplasmic reticulum (ER) and disaggregation of ribosomes, and (d) areas of focal cytoplasmic degradation. These changes, although not specific, clearly suggest that aflatoxin B₁ is a pancreaticotoxic agent.

Original language	English (US)
Pages (from-to)	149-157
Number of pages	9
Journal	Virchows Archiv B Cell Pathology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/BF02912843
State	Published - Dec 1975

ASJC Scopus subject areas

Pathology and Forensic Medicine

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The ultrastructural effects of aflatoxin B₁ in the rat pancreas

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