The acute effects of aflatoxin B1 (AFB1) on the morphology of the acinar cells of the exocrine pancreas were studied in rats. By light microscopy, the changes were unremarkable except for slight decrease in number of zymogen granules. By electron microscopy, the changes observed were: (a) decrease in the number of zymogen granules and irregularity of the limiting membrane, (b) dilatation of Golgi vesicles, (c) dilatation of endoplasmic reticulum (ER) and disaggregation of ribosomes, and (d) areas of focal cytoplasmic degradation. These changes, although not specific, clearly suggest that aflatoxin B1 is a pancreaticotoxic agent.
ASJC Scopus subject areas
- Pathology and Forensic Medicine