The uptake of [3h] γ-aminobutyric acid by isolated glial (müller) cells from the mouse retina

P. Vijay Sarthy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We have examined the uptake of [3H]GABA by isolated glial (Müller) cells using light microscope autoradiography. The aim of these studies was to determine whether Müller cells dissociated from papain-treated mouse retina have the capacity to accumulate exogenous GABA and to further characterize the uptake process. Our results show that isolated Müller cells retain the capacity to accumulate exogenous [3H]GABA and this uptake is inhibited by excess GABA, DABA and β-alanine. This communication also describes a new method for performing light microscope autoradiography.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalJournal of Neuroscience Methods
Volume5
Issue number1-2
DOIs
StatePublished - Jan 1982

Keywords

  • GABA uptake
  • Müller cell
  • glia
  • isolated cell
  • retina

ASJC Scopus subject areas

  • Neuroscience(all)

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