Abstract
Photochemical attachment of synthetic oligonucleotides on the three dimensional surface of a polyacrylamide based hydrogel was used in the specific detection of target oligonucleotides. Covalent attachment of the oligonucleotide to the hydrogel was mediated by the incorporation of a 2+2 photo-attachable functional group in both the hydrogel and the oligonucleotide probe. Expression and SNP assays were used to evaluate this platform.
Original language | English (US) |
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Pages (from-to) | 1371-1375 |
Number of pages | 5 |
Journal | Nucleosides, Nucleotides and Nucleic Acids |
Volume | 20 |
Issue number | 4-7 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Molecular Medicine
- Biochemistry