Abstract
Indirect immunofluorescence staining in two thymomas, one case of thymic hyperplasia, 10 malignant lymphomas and three seminomas was done with an antibody prepared against keratins from human epidermis. Staining was observed only in the epithelial cells of the thymomas and thymic hyperplasia and correlated well with electron microscopic studies. Immunofluorescence staining of thymic tumors with antikeratin antibody provides a simple, specific, and sensitive method for distinguishing thymoma from lymphoma and seminoma. The method may also prove to be useful in other instances in the distinction between epithelial and nonepithelial tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 635-641 |
| Number of pages | 7 |
| Journal | Human pathology |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1980 |
Funding
There are two major classes of tumors tlmt ittvolve the tltvmus: the ti!yn)onm, wlticlt is derived from epitheliai ceils, and the lymphoma, of lymphocytic origin. The distinction between thymoma and histiocytic lymphoma can sometimes be diffictflt to Accepted fi)r publication July 27, 1979. These investigations were aided I~)' grants from tile National Institutes of tteahh (EY02472. AM25140, AM21358). l)r. Sun was tile recipient of a Research Career I)evelopnlent Award from tile National Eye Institute (EY00125). *Professor of Pathology, Northwestern University Medical School. Director of Surgical Pathology, Northwestern Memorial Hospital, Chicago, Illinois.
ASJC Scopus subject areas
- Pathology and Forensic Medicine