The use of biodegradable nanoparticles for tolerogenic therapy of allergic inflammation

Charles B. Smarr; Stephen D. Miller

doi:10.1007/978-1-4939-7896-0_25

The use of biodegradable nanoparticles for tolerogenic therapy of allergic inflammation

Charles B. Smarr, Stephen D. Miller^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	353-358
Number of pages	6
DOIs	https://doi.org/10.1007/978-1-4939-7896-0_25
State	Published - 2018

Publication series

Name	Methods in Molecular Biology
Volume	1799
ISSN (Print)	1064-3745

Funding

This study was supported by NIH Grant EB013198 and Juvenile Diabetes Research Society Grant 2-SRA-2014-279-Q-R.

Keywords

Allergy
Immunotherapy
Nanoparticles
Th2
Tolerance

ASJC Scopus subject areas

Genetics
Molecular Biology

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10.1007/978-1-4939-7896-0_25

Cite this

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abstract = "Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.",

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AB - Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.

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KW - Tolerance

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The use of biodegradable nanoparticles for tolerogenic therapy of allergic inflammation

Abstract

Publication series

Funding

Keywords

ASJC Scopus subject areas

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