The use of biodegradable nanoparticles for tolerogenic therapy of allergic inflammation

Charles B. Smarr, Stephen D. Miller*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages353-358
Number of pages6
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1799
ISSN (Print)1064-3745

Keywords

  • Allergy
  • Immunotherapy
  • Nanoparticles
  • Th2
  • Tolerance

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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