The use of bone morphogenetic protein gene therapy in craniofacial bone repair

Tord D. Alden, Elisa J. Beres, Jeffrey S. Laurent, Johnathan A. Engh, Subinoy Das, Scott D. London, John A. Jane, Sarah B. Hudson, Gregory A. Helm*

*Corresponding author for this work

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Bone morphogenetic proteins (BMPs) are capable of inducing endochondral bone formation when applied on biologic carriers in numerous mammalian in vivo assay systems. Bone morphogenetic protein gene therapy is also currently being developed to promote osteogenesis for clinical indications such as spinal fusions, craniofacial bone loss, and osteoporosis. In this study, critical-sized mandibular defects were treated with a control adenoviral vector (Ad-β-gal), a BMP-2 adenoviral vector (Ad-BMP-2), or a BMP-9 adenoviral vector (Ad-BMP-9). Gross tissue examination, radiographic analysis, and histologic analysis demonstrated significant bony healing in the BMP treated groups compared to controls. Osteogenesis was limited to the bony defect, without extension into the surrounding soft tissues. The study suggests that with further development, BMP gene therapy may be potentially useful for repair of bony defects in the craniofacial region.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalJournal of Craniofacial Surgery
Volume11
Issue number1
DOIs
StatePublished - Jan 2000

Keywords

  • Adenovirus
  • BMP-2
  • BMP-9
  • Gene therapy
  • Osteogenesis

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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