The use of hypomethylating agents in the treatment of hematologic malignancies

Jane E. Kihslinger, Lucy A. Godley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Epigenetic alterations, such as DNA methylation and histone modifications, are abnormal in cancer cells, and the use of the hypomethylating agents 5-azacitidine and decitabine are important additions to our arsenal of active cancer drugs, especially for the treatment of the myelodysplastic syndromes and acute myeloid leukemia. Most effective are repeated cycles of the drugs given at doses much lower than originally tested. Typical overall response rates (complete responses + partial responses + hematologic improvement) for both drugs are in the range of 40-50%. These agents are generally very well tolerated, with myelosuppression being the major side effect. Postulated to work through hypomethylation of DNA causing induction of gene expression, the precise mechanism of action of these agents is not yet clear. Future studies are likely to combine these agents with other drugs like the histone deacetylase inhibitors that act in related pathways.

Original languageEnglish (US)
Pages (from-to)1676-1695
Number of pages20
JournalLeukemia and Lymphoma
Volume48
Issue number9
DOIs
StatePublished - Sep 2007

Keywords

  • 5-Azacitidine
  • Decitabine
  • Hematologic malignancies

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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