The utility of aminoglycosides in an era of emerging drug resistance

Teresa R. Zembower, Gary A. Noskin, Michael J. Postelnick, Chieu Nguyen, Lance R. Peterson*

*Corresponding author for this work

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalInternational Journal of Antimicrobial Agents
Volume10
Issue number2
DOIs
StatePublished - May 21 1998

Keywords

  • Aminoglycoside
  • Antibiotic
  • Antimicrobial drug resistance
  • Nosocomial infection
  • Synergy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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