The utility of aminoglycosides in an era of emerging drug resistance

Teresa R. Zembower; Gary A. Noskin; Michael J. Postelnick; Chieu Nguyen; Lance R. Peterson

doi:10.1016/S0924-8579(98)00033-8

The utility of aminoglycosides in an era of emerging drug resistance

Teresa R. Zembower, Gary A. Noskin, Michael J. Postelnick, Chieu Nguyen, Lance R. Peterson^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.

Original language	English (US)
Pages (from-to)	95-105
Number of pages	11
Journal	International Journal of Antimicrobial Agents
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0924-8579(98)00033-8
State	Published - May 21 1998

Keywords

Aminoglycoside
Antibiotic
Antimicrobial drug resistance
Nosocomial infection
Synergy

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0924-8579(98)00033-8

Cite this

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title = "The utility of aminoglycosides in an era of emerging drug resistance",

abstract = "As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.",

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AU - Noskin, Gary A.

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AU - Nguyen, Chieu

AU - Peterson, Lance R.

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N2 - As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.

AB - As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.

KW - Aminoglycoside

KW - Antibiotic

KW - Antimicrobial drug resistance

KW - Nosocomial infection

KW - Synergy

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The utility of aminoglycosides in an era of emerging drug resistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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