The vascular adventitia: Its role in the arterial injury response

George E. Havelka, Melina R. Kibbe*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The belief that the adventitia serves only a structural purpose has changed over the last decade. Studies have begun to elucidate the role the adventitia plays in the arterial response to injury. The adventitial fibroblast plays an integral part in the development of neointimal hyperplasia. Adiponectin, an adipokine produced from periadventitial adipose tissue, exhibits numerous vasoprotective properties. Stem cells arise, in part, from the adventitia, and stem cell recruitment into the adventitia from the vasa vasorum has been shown to be important in the development of neointimal hyperplasia. The exact role the vasa vasorum plays in neointimal growth is poorly understood and different studies endorse conflicting viewpoints. Thus, understanding the nuances of adventitial pathophysiology will allow us to better appreciate the mechanisms behind the pathology of neointimal hyperplasia. This review will summarize recent findings on the active role the adventitia plays toward the development of neointimal hyperplasia.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalVascular and Endovascular Surgery
Issue number5
StatePublished - Jul 2011


  • adiponectin
  • adventitia
  • neointimal hyperplasia
  • nitric oxide
  • reactive oxygen species
  • stem cells
  • vasa vasorum

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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