The vav proto-oncogene product (p95(vav)) interacts with the Tyk-2 protein tyrosine kinase

Shahab Uddin, Michelle Sweet, Oscar R. Colamonici, John J. Krolewski, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The vav proto-oncogene product participates in the signaling pathways activated by various cell-surface receptors, including the type I IFN receptor. During engagement of the type I IFN receptor, p95(vav) is phosphorylated on tyrosine residues, but the kinase regulating its phosphorylation has not been identified to date. Our studies demonstrate that p95(vav) forms a stable complex with the IFN-receptor-associated Tyk-2 kinase in vivo, and strongly suggest that this kinase regulates its phosphorylation on tyrosine. Thus, p95(vav) is engaged in IFN-signaling by a direct interaction with the functional type I IFN receptor complex to transduce downstream signals.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalFEBS Letters
Volume403
Issue number1
DOIs
StatePublished - Feb 10 1997

Keywords

  • Interferon signaling
  • Jak kinase
  • vav Proto-oncogene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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