The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

Jantje M. Gerdes, Erica Ellen Davis, Elias Nicholas Katsanis*

*Corresponding author for this work

Research output: Contribution to journalReview article

489 Scopus citations

Abstract

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

Original languageEnglish (US)
Pages (from-to)32-45
Number of pages14
JournalCell
Volume137
Issue number1
DOIs
StatePublished - Apr 3 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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