The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice

Hee Kyung Hong, Janice K. Noveroske, Denis J. Headon, Tong Liu, Man Sun Sy, Monica J. Justice, Aravinda Chakravarti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Satin (sa) homozygous mice have a silky coat with high sheen arising from structurally abnormal medulla cells and defects in differentiation of the hair shaft. We demonstrate that the winged helix/forkhead transcription factor, Foxq1 (Forkhead box, subclass q, member 1) is mutant in sa mice. An intragenic deletion was identified in the radiation-induced satin mutant of the SB/Le inbred strain; a second allele, identified by an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, has a missense mutation in the conserved winged helix DNA-binding domain. Homozygous mutants of the two alleles are indistinguishable. We show that Foxq1 is expressed during embryogenesis and exhibits a tissue-restricted expression pattern in adult tissues. The hair defects appear to be restricted to the inner structures of the hair; consequently, Foxq1 has a unique and distinct function involved in differentiation and development of the hair shaft. Despite an otherwise healthy appearance, satin mice have been reported to exhibit suppressed NK-cell function and alloimmune cytotoxic T-cell function. We show instead that the immune defects are attributable to genetic background differences.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalGenesis
Volume29
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Foxq1
  • Hair differentiation
  • Satin
  • Winged helix/forkhead transcription factor

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology

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