The yeast frameshift suppressor gene SUF16-1 encodes an altered glycine tRNA containing the four-base anticodon 3'-CCCG-5'

Richard F. Gaber*, Michael R. Culbertson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The SUFI 6 frameshift suppressor locus encodes a glycine tRNA. The SUF16-1 suppressor tRNA is inferred by DNA sequence analysis to contain the four-base anticodon sequence 3'-CCCG-5' in place of the wild-type anticodon 3'-CCG-5'. SUF16-1 mediates translation of the four-base messenger RNA (mRNA) sequence 5'-GGGU-3' but apparently fails to act at the sequence 5'-GGGG-3'. A molecular model is presented that accounts for the observed specificity of tRNA-mediated frameshift suppression in Saccharomyces cerevisiae.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalGene
Volume19
Issue number2
DOIs
StatePublished - Sep 1982

Keywords

  • S sequence
  • Saccharomyces cerevisiae
  • non-triplet decoding

ASJC Scopus subject areas

  • Genetics

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