Theiler’s virus antigen detected in mouse spinal cord 2½ years after infection

Howard L. Lipton; Jon Kratochvil; Pradip Sethi; Mauro C.Dal Canto

doi:10.1212/wnl.34.8.1117

Theiler’s virus antigen detected in mouse spinal cord 2½ years after infection

Howard L. Lipton^*, Jon Kratochvil, Pradip Sethi, Mauro C.Dal Canto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Spinal cord sections from mice injected with Theiler’s murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2½ years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque- forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.

Original language	English (US)
Pages (from-to)	1117-1119
Number of pages	3
Journal	Neurology
Volume	34
Issue number	8
DOIs	https://doi.org/10.1212/wnl.34.8.1117
State	Published - Aug 1984
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/wnl.34.8.1117

Cite this

@article{9a1e1423edd84d66a12f1663056e262e,

title = "Theiler{\textquoteright}s virus antigen detected in mouse spinal cord 2½ years after infection",

abstract = "Spinal cord sections from mice injected with Theiler{\textquoteright}s murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2½ years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque- forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.",

author = "Lipton, {Howard L.} and Jon Kratochvil and Pradip Sethi and Canto, {Mauro C.Dal}",

year = "1984",

month = aug,

doi = "10.1212/wnl.34.8.1117",

language = "English (US)",

volume = "34",

pages = "1117--1119",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Theiler’s virus antigen detected in mouse spinal cord 2½ years after infection

AU - Lipton, Howard L.

AU - Kratochvil, Jon

AU - Sethi, Pradip

AU - Canto, Mauro C.Dal

PY - 1984/8

Y1 - 1984/8

N2 - Spinal cord sections from mice injected with Theiler’s murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2½ years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque- forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.

AB - Spinal cord sections from mice injected with Theiler’s murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2½ years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque- forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0021256645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021256645&partnerID=8YFLogxK

U2 - 10.1212/wnl.34.8.1117

DO - 10.1212/wnl.34.8.1117

M3 - Article

C2 - 6087205

AN - SCOPUS:0021256645

SN - 0028-3878

VL - 34

SP - 1117

EP - 1119

JO - Neurology

JF - Neurology

IS - 8

ER -

Theiler’s virus antigen detected in mouse spinal cord 2½ years after infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this