Theiler’s virus antigen detected in mouse spinal cord 2½ years after infection

Howard L. Lipton*, Jon Kratochvil, Pradip Sethi, Mauro C.Dal Canto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Spinal cord sections from mice injected with Theiler’s murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2½ years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque- forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.

Original languageEnglish (US)
Pages (from-to)1117-1119
Number of pages3
JournalNeurology
Volume34
Issue number8
DOIs
StatePublished - Aug 1984

ASJC Scopus subject areas

  • Clinical Neurology

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