Theiler's virus-induced demyelination: Prevention by immunosuppression

Howard L. Lipton*, Mauro C. Dal Canto

*Corresponding author for this work

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

The effect of immunosuppression with cyclophosphamide and rabbit antiserum to mouse thymocytes on demyelination induced by Theiler's virus in SJL/J mice was ascertained from Epon-embedded sections (1 micrometer) of the central nervous system. Immunosuppression not only eliminated mononuclear cell infiltrates in the spinal cord white matter, but it also prevented the occurrence of demyelination. These results suggest that demyelination in this infection is immune-mediated.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalScience
Volume192
Issue number4234
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • General

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