Keyphrases
Inactivator
100%
GABA-transaminase
100%
Kinetic Parameters
100%
Theoretical Validation
100%
Global Kinetics
100%
Mechanistic Validation
100%
Inactivation Mechanism
50%
GABA-AT
50%
Mechanism-based
33%
Rate-limiting Step
33%
Deprotonation
33%
Quantum Mechanical Calculations
33%
Progress Curve Analysis
33%
Amino
16%
Molecular Dynamics Simulation
16%
Cluster Model
16%
Quantum Mechanical
16%
Aminotransferase
16%
Computational Chemistry
16%
Binding Complex
16%
Structural Difference
16%
Aminobutyric Acid
16%
Kinetic Isotope Effect
16%
Double Bond
16%
Deuterium Isotope Effect
16%
Carboxylic Acids
16%
Quantum Mechanical Models
16%
Configurational Entropy
16%
Entropy Loss
16%
Geometric Criterion
16%
Inactivation Effect
16%
Natural Bond Orbital
16%
Transition State Stabilization
16%
Ground-state Destabilization
16%
Binding Isotope Effect
16%
Inhibitor Constant
16%
Chemistry
Pharmacokinetics
100%
CPP
100%
Gamma-Aminobutyric Acid
100%
Deprotonation
40%
Kinetic Isotope Effect
40%
Kinact
40%
Ground State
20%
Kd
20%
Cluster Model
20%
Transition State
20%
Natural Bond Orbital Analysis
20%
Computational Chemistry
20%
Double Bond
20%
Molecular dynamics simulation
20%
Carboxylic Acid
20%
Isotope Effect
20%
Biochemistry, Genetics and Molecular Biology
Kinetic Parameter
100%
Transaminase
100%
Gamma-Aminobutyric Acid
100%
Enzyme
60%
Kinetic Isotope Effect
40%
Inactivation Rate Constant
40%
Deprotonation
40%
Computer Simulation
20%
Engineering
Limiting Step
100%
Curve Analysis
100%
Kinetic Parameter
100%
Mechanical Model
50%
Double Bond
50%
Computer Simulation
50%
Ground State
50%
Pharmacology, Toxicology and Pharmaceutical Science
4 Aminobutyric Acid
100%
4 Aminobutyrate Aminotransferase
100%
Enzyme Inhibitor
66%
Carboxylate
33%
Double Bond
33%
Deuterium
33%