Therapeutic applications of spherical nucleic acids

Stacey N. Barnaby, Timothy L. Sita, Sarah Hurst Petrosko, Alexander H Stegh, Chad A Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Spherical nucleic acids (SNAs) represent an emerging class of nanoparticlebased therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over traditional nucleic acid delivery methods, including entry into nearly all cells independent of transfection agents and resistance to nuclease degradation. Furthermore, SNAs can penetrate biological barriers, including the blood–brain and blood–tumor barriers as well as the epidermis, and have demonstrated efficacy in several murine disease models in the absence of significant adverse side effects. In this chapter, we will focus on the applications of SNAs in cancer therapy as well as discuss multimodal SNAs for drug delivery and imaging.

Original languageEnglish (US)
Pages (from-to)23-50
Number of pages28
JournalCancer treatment and research
Volume166
DOIs
StatePublished - Jan 1 2015

Fingerprint

Nucleic Acids
Oligonucleotides
Therapeutics
Platinum
Epidermis
Silicon Dioxide
Gold
Nanoparticles
Transfection
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cancer
  • Nanoparticles
  • SNAs
  • Spherical nucleic acids
  • Therapeutics
  • siRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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abstract = "Spherical nucleic acids (SNAs) represent an emerging class of nanoparticlebased therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over traditional nucleic acid delivery methods, including entry into nearly all cells independent of transfection agents and resistance to nuclease degradation. Furthermore, SNAs can penetrate biological barriers, including the blood–brain and blood–tumor barriers as well as the epidermis, and have demonstrated efficacy in several murine disease models in the absence of significant adverse side effects. In this chapter, we will focus on the applications of SNAs in cancer therapy as well as discuss multimodal SNAs for drug delivery and imaging.",
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Therapeutic applications of spherical nucleic acids. / Barnaby, Stacey N.; Sita, Timothy L.; Petrosko, Sarah Hurst; Stegh, Alexander H; Mirkin, Chad A.

In: Cancer treatment and research, Vol. 166, 01.01.2015, p. 23-50.

Research output: Contribution to journalArticle

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AU - Barnaby, Stacey N.

AU - Sita, Timothy L.

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AU - Stegh, Alexander H

AU - Mirkin, Chad A

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