Therapeutic Immune Tolerance Approaches for the Treatment of Allergic Disease

C. B. Smarr*, D. R. Getts, Stephen D Miller

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Induction of antigen-specific immune tolerance is the desired goal for the treatment of autoimmune and allergic diseases and protection of transplanted cells and tissues. In the context of allergy, specific immunotherapy (SIT) is the only treatment option that directly targets the Th2 bias underlying allergy, but requires a long period of dose escalation with soluble antigen and carries a significant risk of adverse reactions. In this chapter, we discuss the role of Th2 cells and B cells in mediating allergic reactions and explain more recent alternate methods of inducing tolerance for the treatment of allergic disease. These include the intravenous administration of apoptotic leukocytes complexed with antigen or biodegradable poly(lactide-. co-glycolide) nanoparticles encapsulating antigen [PLG(Ag)]. PLG(Ag) nanoparticles effectively inhibit Th2 responses and allergic inflammation both prophylactically and therapeutically and are being clinically developed for allergy therapy.

Original languageEnglish (US)
Title of host publicationTranslational Immunology
Subtitle of host publicationMechanisms and Pharmacologic Approaches
PublisherElsevier Inc
Pages259-284
Number of pages26
ISBN (Print)9780128015773
DOIs
StatePublished - Dec 19 2015

Keywords

  • Allergy
  • Anergy
  • Immunotherapy
  • PLG nanoparticles
  • Regulatory T cells
  • Tolerance

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Smarr, C. B., Getts, D. R., & Miller, S. D. (2015). Therapeutic Immune Tolerance Approaches for the Treatment of Allergic Disease. In Translational Immunology: Mechanisms and Pharmacologic Approaches (pp. 259-284). Elsevier Inc. https://doi.org/10.1016/B978-0-12-801577-3.00011-3