Therapeutic response to octreotide in patients with refractory CPT-11 induced diarrhea

Barbara Pro, Richard Lozano, Jaffer A. Ajani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose. Severe diarrhea can represent a dose-limiting toxicity with the use of CPT-11. Conventional therapy is ineffective in some patients and is also limited by patient compliance. We report our observation on the effectiveness of octreotide acetate in the treatment of CPT-11-induced diarrhea refractory to opioids. Patients and methods. We describe 4 patients with metastatic gastrointestinal tumors who developed severe diarrhea following treatment with CPT-11 (65-125 mg/m2/weekly for 4 weeks every 6 weeks). Diarrhea was refractory to treatment with loperamide and diphenoxylate and was treated with octreotide acetate. Results. Complete resolution of diarrhea was observed within 2-4 days of octreotide acetate treatment. Three patients responded to SC octreotide given every 8 hours and the 4th patient to octreotide given by continuous SC infusion. Conclusions. Our preliminary observation suggests value of octreotide in the control of CPT-11 induced refractory diarrhea. Prospective studies are warranted.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalInvestigational New Drugs
Volume19
Issue number4
DOIs
StatePublished - 2001

Keywords

  • CPT-11
  • Diarrhea
  • Octreotide acetate
  • Somatostatin analogue

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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