Therapeutic strategies in eosinophilic esophagitis: Induction, maintenance and refractory disease

Jamie Sodikoff, Ikuo Hirano*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease that is increasingly recognized as one of the most common causes of dysphagia and foregut symptoms in adults and children. Topical corticosteroids, elimination diets, and esophageal dilations are effective options for both induction and maintenance therapy in EoE. Current pharmacologic options are being used off-label as no agent has yet been approved by regulatory authorities. Little is known about the natural history of EoE, however, raising controversy regarding the necessity of maintenance and therapy in asymptomatic or treatment-refractory patients. Furthermore, variability in treatment endpoints used in EoE clinical trials makes interpretation and comparability of EoE treatments challenging. Recent validation of a patient-related outcome (PRO) instruments, a histologic scoring tool, and an endoscopic grading system for EoE are significant advances toward establishing consistent treatment endpoints.

Original languageEnglish (US)
Pages (from-to)829-839
Number of pages11
JournalBest Practice and Research: Clinical Gastroenterology
Volume29
Issue number5
DOIs
StatePublished - Oct 2015

Keywords

  • Dysphagia
  • Eosinophilic esophagitis
  • Eosinophilic gastroenteritis
  • Esophageal dilation
  • Esophageal stricture
  • Gastroesophageal reflux disease

ASJC Scopus subject areas

  • Gastroenterology

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