Therapeutic Use of Factor VIII

Research output: Contribution to journalLetter

Abstract

To the Editor: We agree with Skinner and Schwartz1 that cautious interpretation of the results of immunosuppressive therapy in patients with anti-factor VIII antibodies is justified. However, to suggest that massive doses of concentrated factor VIII alone will more than temporarily control such circulating anticoagulants is unwarranted. In the report on which this statement was based,2 the inhibitor noted in two of three patients completely disappeared after combined therapy with both factor VIII concentrate and azathioprine. The third, a 72-year-old hemophilic patient, had an unusual inhibitor in that factor VIII and inhibitor were simultaneously present prior to therapy. The disappearance.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume287
Issue number16
DOIs
StatePublished - Oct 19 1972

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Factor VIII
Therapeutic Uses
Azathioprine
Immunosuppressive Agents
Therapeutics
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Therapeutic Use of Factor VIII",
abstract = "To the Editor: We agree with Skinner and Schwartz1 that cautious interpretation of the results of immunosuppressive therapy in patients with anti-factor VIII antibodies is justified. However, to suggest that massive doses of concentrated factor VIII alone will more than temporarily control such circulating anticoagulants is unwarranted. In the report on which this statement was based,2 the inhibitor noted in two of three patients completely disappeared after combined therapy with both factor VIII concentrate and azathioprine. The third, a 72-year-old hemophilic patient, had an unusual inhibitor in that factor VIII and inhibitor were simultaneously present prior to therapy. The disappearance.",
author = "D. Green",
year = "1972",
month = "10",
day = "19",
doi = "10.1056/NEJM197210192871613",
language = "English (US)",
volume = "287",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
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Therapeutic Use of Factor VIII. / Green, D.

In: New England Journal of Medicine, Vol. 287, No. 16, 19.10.1972.

Research output: Contribution to journalLetter

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T1 - Therapeutic Use of Factor VIII

AU - Green, D.

PY - 1972/10/19

Y1 - 1972/10/19

N2 - To the Editor: We agree with Skinner and Schwartz1 that cautious interpretation of the results of immunosuppressive therapy in patients with anti-factor VIII antibodies is justified. However, to suggest that massive doses of concentrated factor VIII alone will more than temporarily control such circulating anticoagulants is unwarranted. In the report on which this statement was based,2 the inhibitor noted in two of three patients completely disappeared after combined therapy with both factor VIII concentrate and azathioprine. The third, a 72-year-old hemophilic patient, had an unusual inhibitor in that factor VIII and inhibitor were simultaneously present prior to therapy. The disappearance.

AB - To the Editor: We agree with Skinner and Schwartz1 that cautious interpretation of the results of immunosuppressive therapy in patients with anti-factor VIII antibodies is justified. However, to suggest that massive doses of concentrated factor VIII alone will more than temporarily control such circulating anticoagulants is unwarranted. In the report on which this statement was based,2 the inhibitor noted in two of three patients completely disappeared after combined therapy with both factor VIII concentrate and azathioprine. The third, a 72-year-old hemophilic patient, had an unusual inhibitor in that factor VIII and inhibitor were simultaneously present prior to therapy. The disappearance.

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JO - New England Journal of Medicine

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