Therapy of endocrine disease: Islet transplantation for type 1 diabetes: So close and yet so far away

Mohsen Khosravi-Maharlooei, Ensiyeh Hajizadeh-Saffar, Yaser Tahamtani, Mohsen Basiri, Leila Montazeri, Keynoosh Khalooghi, Mohammad Kazemi Ashtiani, Ali Farrokhi, Nasser Aghdami, Anavasadat Sadr Hashemi Nejad, Mohammad Bagher Larijani, Nico De Leu, Harry Heimberg, Xunrong Luo, Hossein Baharvand*

*Corresponding author for this work

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.

Original languageEnglish (US)
Pages (from-to)R165-R183
JournalEuropean Journal of Endocrinology
Volume173
Issue number5
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Khosravi-Maharlooei, M., Hajizadeh-Saffar, E., Tahamtani, Y., Basiri, M., Montazeri, L., Khalooghi, K., Ashtiani, M. K., Farrokhi, A., Aghdami, N., Hashemi Nejad, A. S., Larijani, M. B., De Leu, N., Heimberg, H., Luo, X., & Baharvand, H. (2015). Therapy of endocrine disease: Islet transplantation for type 1 diabetes: So close and yet so far away. European Journal of Endocrinology, 173(5), R165-R183. https://doi.org/10.1530/EJE-15-0094