Therapy of Peripheral T Cell Lymphoma: Focus on Nodal Subtypes

Pamela B. Allen, Barbara Pro*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas with inferior prognosis compared with their B cell counterparts characterized by frequent relapses, resulting in a median 5-year survival of approximately 30%. Their diverse clinicopathologic features challenge existing treatment paradigms that treat all patients uniformly. Here we review recent advances in the treatment of these diseases. Recent Findings: While current treatment still relies largely on combination chemotherapy, the introduction of more effective novel and targeted therapies has improved outcomes in certain subtypes. Increasing understanding of the underlying biology of PTCL has prompted further subclassification by genetic and molecular subgroups. Summary: Overall, the most significant advances in PTCL management have resulted from improved understanding and classification of the biology of PTCL. Ongoing development of subtype-specific targeted therapies will be essential to improve long-term outcomes of patients with these diseases.

Original languageEnglish (US)
Article number44
JournalCurrent oncology reports
Volume22
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • Anaplastic large-cell lymphoma
  • Angioimmunoblastic T cell lymphoma
  • Peripheral T cell lymphoma
  • Relapsed disease
  • Therapy

ASJC Scopus subject areas

  • Oncology

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