Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature

Astrid Wintering, Stephen Smith, Beng Fuh, Arun Rangaswami, Gary Dahl, May Chien, Tanja A. Gruber, Jinjun Dang, Loretta S. Li, Alicia Lenzen, Stephanie Savelli, Christopher C. Dvorak, Anurag K. Agrawal, Elliot Stieglitz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Therapy-related myeloid neoplasms (t-MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy-related myelodysplastic syndrome (t-MDS), therapy-related myeloproliferative neoplasms (t-MPN) and therapy-related acute myeloid leukemia (t-AML). Here, we report a series of patients with clinical features consistent with juvenile myelomonocytic leukemia (JMML), an overlap syndrome of MDS and myeloproliferative neoplasms that developed after treatment for another malignancy.

Original languageEnglish (US)
Article numbere29499
JournalPediatric Blood and Cancer
Volume69
Issue number5
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • AML
  • JMML
  • MDS
  • secondary
  • therapy related

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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