There is fat in this sclerosis: A case report of sclerotic lipoma and review of the literature

Yan Xiang*, Ata S. Moshiri, Edward F. Chan, Trisha S. Dasgupta, Heidi Kozic, Rosalie Elenitsas, Cuong V. Nguyen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Sclerotic lipomas, a lipoma variant, are benign subcutaneous tumors, so-named because of their resemblance to sclerotic fibromas. Previous literature has suggested that these tumors may show a predilection for middle-aged adult males. We report an unusual case of a sclerotic lipoma diagnosed on the scalp of a 66-year-old female. The patient presented to the outpatient clinic with a 3- to 4-year history of an enlarging and irritated 2.6-cm nodule on the anterior crown of the scalp, clinically thought to be a pilar cyst. Histopathological examination from the excisional specimen revealed a well-circumscribed dermal to subcutaneous tumor with ample sclerotic collagen bundles, an increased number of CD34 positive spindled cells, and prominent S-100 positive mature adipocytes comprising greater than 50% of the tumor. We present this case given its atypical clinical and histopathological presentation, review the literature of sclerotic lipomas, and discuss the differential diagnosis to raise awareness of this rare entity.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalJournal of cutaneous pathology
Issue number3
StatePublished - Mar 1 2020


  • lipoma variant
  • sclerosing fibroma
  • sclerotic lipoma
  • spindle cell lipoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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