Thermally active hybridization drives the crystallization of DNA-functionalized nanoparticles

Ting I.N.G. Li, Rastko Sknepnek, Monica Olvera De La Cruz*

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The selectivity of DNA recognition inspires an elegant protocol for designing versatile nanoparticle (NP) assemblies. We use molecular dynamics simulations to analyze dynamic aspects of the assembly process and identify ingredients that are key to a successful assembly of NP superlattices through DNA hybridization. A scale-accurate coarse-grained model faithfully captures the relevant contributions to the kinetics of the DNA hybridization process and is able to recover all experimentally reported to date binary superlattices (BCC, CsCl, AlB2, Cr3Si, and Cs6C60). We study the assembly mechanism in systems with up to 106 degrees of freedom and find that the crystallization process is accompanied with a slight decrease of enthalpy. Furthermore, we find that the optimal range of the DNA linker interaction strengths for a successful assembly is 12-16kBT, and the optimal mean lifetime of a DNA hybridization event is 10 -4-10-3 of the total time it takes to form a crystal. We also obtain the optimal percentage of hybridized DNA pairs for different binary systems. On the basis of these results, we propose suitable linker sequences for future nanomaterials design.

Original languageEnglish (US)
Pages (from-to)8535-8541
Number of pages7
JournalJournal of the American Chemical Society
Volume135
Issue number23
DOIs
StatePublished - Jun 12 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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