Thermally processed polymeric microparticles for year-long delivery of dexamethasone

Amy C. Goodfriend, Tré R. Welch, Kytai T. Nguyen, Romaine F. Johnson, Vinod Sebastian, Surendranath Veeram Reddy, Joseph Forbess, Alan Nugent*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dexamethasone-releasing poly(lactic-co-glycolic acid) (PLGA) microparticles were formulated using a solvent displacement technique with the addition of distillation aiming to increase drug delivery lifetime. Two PLGA copolymer ratios (50:50 and 75:25) were used to determine the influence of lactic acid and glycolic acid ratio on microparticle characteristics. The addition of distillation significantly slows the release of dexamethasone compared to traditional solvent removal via evaporation while still maintaining a therapeutic dosage. Microparticles formulated with PLGA 50:50 controllably release dexamethasone up to one year and 75:25 release up to two years in-vitro. The ratio of lactic acid to glycolic acid plays a significant role in microparticle stability, drug loading efficiency, and thermal properties. In all, this formulation technique offers new prospects for inflammation suppression in pediatric vascular and airway diseases.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalMaterials Science and Engineering C
Volume58
DOIs
StatePublished - Jan 1 2016

Fingerprint

glycolic acid
microparticles
Dexamethasone
delivery
Distillation
acids
Acids
Lactic Acid
lactic acid
distillation
Lactic acid
Pediatrics
Drug delivery
drugs
Evaporation
Thermodynamic properties
Copolymers
releasing
copolymers
Pharmaceutical Preparations

Keywords

  • Dexamethasone
  • Drug delivery
  • PLGA microparticles
  • Thermal processing

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Goodfriend, Amy C. ; Welch, Tré R. ; Nguyen, Kytai T. ; Johnson, Romaine F. ; Sebastian, Vinod ; Reddy, Surendranath Veeram ; Forbess, Joseph ; Nugent, Alan. / Thermally processed polymeric microparticles for year-long delivery of dexamethasone. In: Materials Science and Engineering C. 2016 ; Vol. 58. pp. 595-600.
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Thermally processed polymeric microparticles for year-long delivery of dexamethasone. / Goodfriend, Amy C.; Welch, Tré R.; Nguyen, Kytai T.; Johnson, Romaine F.; Sebastian, Vinod; Reddy, Surendranath Veeram; Forbess, Joseph; Nugent, Alan.

In: Materials Science and Engineering C, Vol. 58, 01.01.2016, p. 595-600.

Research output: Contribution to journalArticle

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T1 - Thermally processed polymeric microparticles for year-long delivery of dexamethasone

AU - Goodfriend, Amy C.

AU - Welch, Tré R.

AU - Nguyen, Kytai T.

AU - Johnson, Romaine F.

AU - Sebastian, Vinod

AU - Reddy, Surendranath Veeram

AU - Forbess, Joseph

AU - Nugent, Alan

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