Abstract
Multifunctional magnetic nanoparticles encapsulated into a thermoresponsive polymer shell allowed the simultaneous cancer therapy due to the thermo-triggered drug release and a heating for hyperthermia can be performed simultaneously under AC magnetic field. In our study, micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block- poly(ε-caprolaction), P(NIPAAm-co-AAm)-b-PCL, were combined with iron oxide nanoparticles and doxorubicin anti-cancer drug which are self-assembled at the micelles hydrophobic interior. The feasibility of the synthesized magnetic micelles for the simultaneous therapy was demonstrated through drug release test at the hyperthermic temperature.
| Original language | English (US) |
|---|---|
| Title of host publication | Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 |
| Pages | 294-297 |
| Number of pages | 4 |
| Volume | 2 |
| State | Published - Dec 1 2009 |
| Event | Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 - Houston, TX, United States Duration: May 3 2009 → May 7 2009 |
Other
| Other | Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 |
|---|---|
| Country/Territory | United States |
| City | Houston, TX |
| Period | 5/3/09 → 5/7/09 |
Keywords
- Drug delivery
- Hyperthermia
- Magnetic nanoparticles
- Thermoresponsive materials
ASJC Scopus subject areas
- Biotechnology
- Biomedical Engineering
- Biomaterials
