Thermoresponsive magnetic micelles for simultaneous magnetic hyperthermia and drug delivery

Dong Hyun Kim, Elena A. Rozhkova, Tijana Rajh, Samuel D. Bader, Valentyn Novosad*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Multifunctional magnetic nanoparticles encapsulated into a thermoresponsive polymer shell allowed the simultaneous cancer therapy due to the thermo-triggered drug release and a heating for hyperthermia can be performed simultaneously under AC magnetic field. In our study, micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block- poly(ε-caprolaction), P(NIPAAm-co-AAm)-b-PCL, were combined with iron oxide nanoparticles and doxorubicin anti-cancer drug which are self-assembled at the micelles hydrophobic interior. The feasibility of the synthesized magnetic micelles for the simultaneous therapy was demonstrated through drug release test at the hyperthermic temperature.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009
Pages294-297
Number of pages4
Volume2
StatePublished - Dec 1 2009
EventNanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 - Houston, TX, United States
Duration: May 3 2009May 7 2009

Other

OtherNanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites - 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009
CountryUnited States
CityHouston, TX
Period5/3/095/7/09

Keywords

  • Drug delivery
  • Hyperthermia
  • Magnetic nanoparticles
  • Thermoresponsive materials

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials

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  • Cite this

    Kim, D. H., Rozhkova, E. A., Rajh, T., Bader, S. D., & Novosad, V. (2009). Thermoresponsive magnetic micelles for simultaneous magnetic hyperthermia and drug delivery. In Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 (Vol. 2, pp. 294-297)