TY - JOUR
T1 - Thickness network features for prognostic applications in dementia
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Raamana, Pradeep Reddy
AU - Weiner, Michael W.
AU - Wang, Lei
AU - Beg, Mirza Faisal
N1 - Funding Information:
We gratefully acknowledge funding support from Alzheimer Society of Canada Research Program (ASRP), Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR) and Michael Smith Foundation for Health Research (MSFHR). They sincerely thank Dr Michael W. Weiner and the Freesurfer team at University of California, San Francisco for the computation and quality control of Freesurfer processing for ADNI data set.
Funding Information:
Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (from National Institutes of Health grants U01 AG024904 , P30 AG010129 , and K01 AG030514 ), for which complete listing of acknowledgements can be found at http://adni.loni.ucla.edu/wp-content/uploads/how_to_apply/ADNI_Manuscript_Citations.pdf . Data collection and sharing for this project was funded by the ADNI ( National Institutes of Health grant U01 AG024904 ). ADNI is funded by the National Institute on Aging , the National Institute of Biomedical Imaging and Bioengineering , and through generous contributions from the following: Alzheimer's Association ; Alzheimer Drug Discovery Foundation ; BioClinica, Inc ; Biogen Idec Inc ; Bristol-Myers Squibb Foundation ; Eisai ; Elan Pharmaceuticals, Inc ; Eli Lilly and Company ; F. Hoffmann-La Roche Ltd , and its affiliated company Genentech, Inc ; GE Healthcare ; Innogenetics, N.V. ; IXICO Ltd ; Janssen Alzheimer Immunotherapy Research & Development, LLC ; Johnson & Johnson Pharmaceutical Research & Development LLC ; Medpace, Inc ; Merck & Co, Inc ; Meso Scale Diagnostics, LLC ; NeuroRx Research ; Novartis Pharmaceuticals Corporation ; Pfizer ; Piramal Imaging ; Servier ; Synarc Inc ; and Takeda Pharmaceutical Company . The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health ( www.fnih.org ). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. This research was also supported by National Institutes of Health grants P30 AG010129 and K01 AG030514 .
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Regional analysis of cortical thickness has been studied extensively in building imaging biomarkers for early detection of Alzheimer's disease but not its interregional covariation of thickness. We present novel features based on the inter-regional covariation of cortical thickness. Initially, the cortical labels of each subject are partitioned into small patches (graph nodes) by spatial k-means clustering. A graph is then constructed by establishing a link between 2 nodes if the difference in thickness between the nodes is below a certain threshold. From this binary graph, a thickness network is computed using nodal degree, betweenness, and clustering coefficient measures. Fusing them with multiple kernel learning, it is observed that thickness network features discriminate mild cognitive impairment (MCI) converters from controls (CN) with an area under curve (AUC) of 0.83, 74% sensitivity and 76% specificity on a large subset obtained from the Alzheimer's Disease Neuroimaging Initiative data set. A comparison of predictive utility in Alzheimer's disease and/or CN classification (AUC of 0.92, 80% sensitivity [SENS] and 90% specificity [SPEC]), in discriminating CN from MCI (converters and nonconverters combined; AUC of 0.75, SENS and SPEC of 64% and 73%, respectively) and in discriminating between MCI nonconverters and MCI converters (AUC of 0.68, SENS and SPEC of 65% and 64%) is also presented. ThickNet features as defined here are novel, can be derived from a single magnetic resonance imaging scan, and demonstrate the potential for the computer-aided prognostic applications.
AB - Regional analysis of cortical thickness has been studied extensively in building imaging biomarkers for early detection of Alzheimer's disease but not its interregional covariation of thickness. We present novel features based on the inter-regional covariation of cortical thickness. Initially, the cortical labels of each subject are partitioned into small patches (graph nodes) by spatial k-means clustering. A graph is then constructed by establishing a link between 2 nodes if the difference in thickness between the nodes is below a certain threshold. From this binary graph, a thickness network is computed using nodal degree, betweenness, and clustering coefficient measures. Fusing them with multiple kernel learning, it is observed that thickness network features discriminate mild cognitive impairment (MCI) converters from controls (CN) with an area under curve (AUC) of 0.83, 74% sensitivity and 76% specificity on a large subset obtained from the Alzheimer's Disease Neuroimaging Initiative data set. A comparison of predictive utility in Alzheimer's disease and/or CN classification (AUC of 0.92, 80% sensitivity [SENS] and 90% specificity [SPEC]), in discriminating CN from MCI (converters and nonconverters combined; AUC of 0.75, SENS and SPEC of 64% and 73%, respectively) and in discriminating between MCI nonconverters and MCI converters (AUC of 0.68, SENS and SPEC of 65% and 64%) is also presented. ThickNet features as defined here are novel, can be derived from a single magnetic resonance imaging scan, and demonstrate the potential for the computer-aided prognostic applications.
KW - Alzheimer
KW - Cortical thickness
KW - Early detection
KW - Fusion
KW - Mild cognitive impairment
KW - Multiple kernel learning
KW - Network properties
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U2 - 10.1016/j.neurobiolaging.2014.05.040
DO - 10.1016/j.neurobiolaging.2014.05.040
M3 - Article
C2 - 25444603
AN - SCOPUS:84916624596
VL - 36
SP - S91-S102
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - S1
ER -