Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

Bin He, Jing Hu, Xiaoyu Zhang, Hening Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.

Original languageEnglish (US)
Pages (from-to)7498-7502
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number38
StatePublished - Oct 14 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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