Thoracoabdominal Asynchrony is Not Associated with Oxyhemoglobin Saturation in Recovering Premature Infants

Colleen Brennan, Lara Ulm, Samuel Julian, Aaron Hamvas, Thomas Ferkol, Julie Hoffman, Laura Linneman, James Kemp

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Recovering premature infants are at risk for hypoxemia and lack of synchrony between their rib cage and abdomen due to airflow obstruction and poor respiratory compliance. Thoracoabdominal asynchrony (TAA) is a useful marker of resistive and elastic lung properties. Whether TAA predicts oxygenation is unknown. Objectives: We investigated oxyhemoglobin saturation (SpO2%) and TAA (phase angle, φ) in preterm infants with/without high-humidity nasal cannula (HHNC). Methods: A cross-sectional observational study was conducted in 92 infants at 32 weeks' postmenstrual age. We measured SpO2% with pulse oximetry and TAA with φ via respiratory inductance plethysmography in infants (mean gestational age: 26.4 + 1.3 weeks) who required room air (n = 18) or HHNC with/without supplemental oxygen (1-5 liters per minute, FiO2 0.21-0.33, n = 74). We calculated median SpO2% from 24.7 + 10.0 min of quiet sleep and median φ from up to 60 breaths. Results: Infants breathing room air alone had marked TAA (φ = 83.6 + 32.9°, range: 10.9-148.5) as did those receiving varying degrees of ventilatory and oxygen support via HHNC (range of group means, φ = 47.0-90.0°). Infants breathing room air had statically greater median SpO2% than those receiving support (96.3 + 0.6% vs. 91.3 + 0.6%; ANOVA p = 0.001). SpO2% was not associated with TAA in either group (r2 = 0.09). Conclusion: Recovering premature infants exhibited TAA regardless of need for ventilatory support and supplemental oxygen. TAA was not associated with SpO2% in either group. Maintenance of SpO2% does not require correction of TAA.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalNeonatology
Volume111
Issue number4
DOIs
StatePublished - May 1 2017

Keywords

  • High-humidity nasal cannula
  • Hypoxemia
  • Prematurity
  • Respiratory inductance plethysmography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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    Brennan, C., Ulm, L., Julian, S., Hamvas, A., Ferkol, T., Hoffman, J., Linneman, L., & Kemp, J. (2017). Thoracoabdominal Asynchrony is Not Associated with Oxyhemoglobin Saturation in Recovering Premature Infants. Neonatology, 111(4), 297-302. https://doi.org/10.1159/000452787