Three Data-Driven Phenotypes of Multiple Organ Dysfunction Syndrome Preserved from Early Childhood to Middle Adulthood

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3 Scopus citations

Abstract

Multiple organ dysfunction syndrome (MODS) is one of the major causes of death and long-term impairment in critically ill patients. MODS is a complex, heterogeneous syndrome consisting of different phenotypes, which has limited the development of MODS-specific therapies and prognostic models. We used an unsupervised learning approach to derive novel phenotypes of MODS based on the type and severity of six individual organ dysfunctions. In a large, multi-center cohort of pediatric, young and middle-aged adults admitted to three different intensive care units, we uncovered and characterized three distinct data-driven phenotypes of MODS which were reproducible across age groups, where independently associated with outcomes and had unique predictors of in-hospital mortality.

Original languageEnglish (US)
Pages (from-to)1345-1353
Number of pages9
JournalAMIA ... Annual Symposium proceedings. AMIA Symposium
Volume2020
StatePublished - 2020

ASJC Scopus subject areas

  • Medicine(all)

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